At work, I normally set up my Powerbook next to my workstation: I keep all my mail and stuff on the Powerbook, and use my Linux workstation for coding. Given that I've got a dual-monitor setup at home, I suppose it's quite natural that occasionally I will try to move the mouse pointer from one monitor to the other.
You know you've completely lost it, though, when after failing to get the pointer to cross between computers the first time, you slam the pointer harder against the side of the screen, with the unconscious belief that if you just push hard enough, it'll make it across the gap.