Continuing on from: Applications that Changed My Life: screen
The most recent application to change the way I use computers has to be Quicksilver. When you first sit down with Quicksilver, it looks like a clever application launcher. You type command-space and a few letters (or initials) of the application you want to run, and Quicksilver finds and runs it. Very useful, and sure beats tracking the application down in the Finder (or in Windows' ever-changing start menu, in which I can now officially find nothing without searching for five minutes). That said, LaunchBar did that before Quicksilver, and LaunchBar didn't change my life.1
Back in the 90's, during the perpetual floating flamewar between the command-line faithful and the new GUI upstarts, the mainstay of the CLI argument was the power of the pipe. By joining these little tools together, you could do lots of useful things, very quickly.
Quicksilver is the best tool I've seen so far that takes the pipe and makes it part of a GUI. Hidden just under command-space are all your applications, files, contacts, bookmarks and more, and a growing collection of tools to do interesting things with them.
As a trivial example:
Step one: grab a file:

Step two: pick an action:

Step three: pick a target:

Et voila! At every point, Quicksilver will help you with a smart type-ahead find that remembers what you do most often, and pushes those options to the top of the list.
43 folders publishes a lot of useful Quicksilver hints and tips, and also had a recent interview with the creator of Quicksilver that contained these gems:
43 Folders: What are the unique challenges of developing for a Mac audience?
Alcor: We are a very outspoken and discerning bunch. Apple has pretty much spoiled us rotten, Half want speed and half want functionality, but everyone seems to want class. The mix of old school mac and unix users has led to very diverse expectations, but despite their fervor the users are tolerant of inconveniences, eager to troubleshoot, and quite innovative. A lot of the better features of QS came from requests.
43 Folders: What is the best power user Quicksilver trick that nobody uses (or knows about)?
Alcor: Hard to say. People seem to keep finding features that were coded at 5 in the morning and promptly forgotten, so the problem is that nobody knows about them. The best new ones are probably the search contents action and the ability to collect multiple items with comma (B30). It is kinda buggy at the moment, but it will become more and more useful as support for that syntax propagates down to all the plugins.
A co-worker once complained that Quicksilver had ceased to function: because the application is still in beta, copies expire after a month or so to force you to keep current. His complaint wasn't so much that Quicksilver stopped working, it was that his Powerbook was unuseable without Quicksilver. That's pretty high praise.

1 LaunchBar is now playing catch-up, growing to do the same sorts of things Quicksilver does, but it seems to lack the hacker spirit.
Indeed. Quicksilver is the first application that I install on a new computer. It's awesome.
Sounds just like what I've been looking for - Is there anything similar on windows?
Though I guess it wouldn't be able to work the same way on windows...
I own two Macs. My primary machine is my desktop. My secondary machine is an aging Powerbook, bought used, still running Jaguar.
Last week I finally downloaded Quicksilver and tried it out on my desktop. After several minutes of playing with Quicksilver, that was enough to make me go out immediately to order a copy of Panther for my laptop. I had been planning on waiting for Tiger and upgrading both machines simultaneously, but after using Quicksilver, it seems pointless to own a Mac without it.
Sounds lovely... be nice to see a screen recording of it in action.
Yep, I agree. It would be hard to accept not having Quicksilver available. Thanks for showing it to me at the pub the other week (before I was a Mac owner - hard to believe that was ever the case now!)
For Windows, I think ActiveWords is the closest software, feature-wise. GUI-wise, not so much :)
With Alt-Space, a text bar pops up and you can type in short keywords to launch a program or do an action. You can also run scripts ...and I think you can do this on the fly like Quicksilver.
I only have the trial version of ActiveWords so I can't comment much on the script functionality.